qronikuli mieloiduri leikemia turava marika

mielogenuri leikemia sawyisi stadiablasturi krizisi

qronikuli mieloiduri leikemia

qronikuli mielogenuri leikemiisaTvis damaxasiaTebelia citogenetikuri darRveva – e.w. filadelfiuri qromosomis ( Ph ) matarebloba, romelic me-9 da 22-e qromosomebs Soris translokaciis Sedegia

filadelfiuri qromosoma

qronikuli mielogenuri leikemiis dros, translokacia aaqtivebs onkogens, ucvlis ra mas adgilmdebareobas da ganaTavsebs mZlavri, konstituciuri promotoris gverdiT, romelic sxva gens ekuTvnis.

daavadebulTa 95%-Si gvxvdeba e.w.filadelfiuri qromosoma abelsoni (ABL) romelic kodirebs arareceptorul Tirozinkinazas da igi lokilizebulia 9q34. BCR geni romelic kodirebs fosfoproteins lokalizebulia 22q11

paTogenezi filadelfiuri qromosomis formirmirebisas ABL geni wydeba pirvell intronSi,BCR geni sami sakontrolo gamSvebi wertilidan erT-erTSi, BCR da ABL genis fragmentebi erTmaneTs ukavSirdebian Tavi kudis principiT da warmoiqmneba 22-e qromosomaze,es anomaluri qromosoma producirebs defeqtur cilas

fluorescentuli in situ hibridizacia ( FISH meTodi) (wiTeli naTeba me-9 qromosomaze, mwvane naTeba – 22-e qromosomaze filadelfiur qromosomaze aris rogorc mwvane, ise wiTeli naTeba)

mkurnaloba M mas Semdeg rac dadginda qronikuli mielogenuri leikemiis molekuluri safuZveli SemuSavebul iqna mkurnalobis efeqturi saSualeba imatimib mesinati romelic warmoadgens Tirozinkinazas inhibitors daavadebulTa 85% kargad emorCileba mkurnalobas

diagnozis dasasmelad axdenen Zvlis tvinis funqcias

daavadebulTa 95% aqvs sruli citogenetikuri remisia sul mcire 3-3,5 wlis ganmavlobaSi. blisturi krizisis terminalur stadiaze miiRweva sicocxlis 12 Tviani gaxangrZliveba.yvelaze efeqturia aligenuri Zvlis tvinis transplantacia

Ddaavadebis ganawileba sqesis mixedviT mozrdilebSi leikemiis SemTxvevaTa 15% modis qronikul mielogenur leikemiaze da Seadgens 1 an 2 SemTxvevas aTiaTas mosaxleze daavadeba ufro xSiria mamakacebSi (0,013-0,017%) vidre qalebSi (0,001%)

Ddaavadebis memkvidreobiT gadacemis riski vinaidan qronikuli mieloiduri leikemia viTardeba somaturi mutaciis Sedegad is ar gvxvdeba germinaciul ujredebSi da Sesabamisad TaobebSi daavadebis gadacemis riski nulis tolia

Ddaavadebis sixSis ganawileba eTnikur jgufebSi Race/EthnicityMaleFemale All Races2.0 per 100,000 men1.1 per 100,000 women White2.0 per 100,000 men1.2 per 100,000 women Black1.9 per 100,000 men1.2 per 100,000 women Asian/Pacific Islander1.3 per 100,000 men0.7 per 100,000 women American Indian/Alaska Native a a ^^ Hispanic b b 1.6 per 100,000 men1.0 per 100,000 women wlis monacemebiT daavadebul pirTa sasualo asaki iyo 65 weli da varirebda 15-dan 90 wlamde, 20welze dabali asakis avadmyofebi Seadgendnen 2,5%-s, 7,4% iyo 20-34wlis, 10,1% 35-44wlis 13,3% 45-54; 15,5% 55-64; 22,7% 65-74; 9,9%iyo 85welze maRali asikis