The first building with more than 2500 m 2 of active area is already constructed. But there is no investments for technological equipment. - презентация

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2 The first building with more than 2500 m 2 of active area is already constructed. But there is no investments for technological equipment.

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4 The investigations are carried out in the fields of bioorganic and organic chemistry, molecular biology and immunology, biochemistry and biotechnology.

5 Founded in 1964 Founded in 1964 Previous name Previous name President-Organizer President-Organizer Institute of Biologically Active Substances Academician G.B. Elyakov. Acting Director (from 2001). Acting Director (from 2001) Academician V.A. Stonik

6 Total persons Scientific staff – 183, including: Academician of RAS - 2 Corresponding member of RAS - 1 Doctor of Science - 22 Ph. D Young scientists - 34

7 Department of Low Molecular Regulators Department of Low Molecular Regulators Department of the Molecular Immunology Department of the Molecular Immunology Laboratory of the Plant Chemotaxonomy Laboratory of the Plant Chemotaxonomy Laboratory of the Enzyme Chemistry Laboratory of the Enzyme Chemistry Laboratory of the Marine Biochemistry Laboratory of the Marine Biochemistry Laboratory of the Structural and Analytical Methods Laboratory of the Structural and Analytical Methods Laboratory of the Instrumental and Radionuclide Methods Laboratory of the Instrumental and Radionuclide Methods Laboratory of the Biotechnology Laboratory of the Biotechnology Group of the N.M.R.-Spectroscopy Group of the N.M.R.-Spectroscopy Group of the Phytoimmunity Group of the Phytoimmunity Group of the New Medicines and Preventives Group of the New Medicines and Preventives Other Scientific Services Other Scientific Services

8 Laboratory of the Chemistry of Marine Natural Compounds Laboratory of the Chemistry of Marine Natural Compounds Laboratory of the Chemistry of Microbial Metabolites Laboratory of the Chemistry of Microbial Metabolites Laboratory of the Peptide Chemistry Laboratory of the Peptide Chemistry Laboratory of the Organic Synthesis Laboratory of the Organic Synthesis Laboratory of the Chemistry of Natural Quinoid Compounds Laboratory of the Chemistry of Natural Quinoid Compounds Laboratory of the Microbiology Laboratory of the Microbiology Laboratory of the Bioassay Laboratory of the Bioassay Group of the Lipid Chemistry Group of the Lipid Chemistry

9 Laboratory of the Carbohydrate Chemistry Laboratory of the Carbohydrate Chemistry Laboratory of the Chemistry of Non- Infective Immunity Laboratory of the Chemistry of Non- Infective Immunity Laboratory of the Molecular Basics of Antibacterial Immunity Laboratory of the Molecular Basics of Antibacterial Immunity

10 The Marine Experimental Station The Marine Experimental Station Research Vessel «Akademik Oparin» Research Vessel «Akademik Oparin» Department of Scientific Information Department of Scientific Information Department of Patents Department of Patents Vivary Vivary Pilot Group Pilot Group Department of Devices Department of Devices Group of Glassware Group of Glassware Laboratory of the Trade Ecology Laboratory of the Trade Ecology Group of Marketing Group of Marketing

11 (Pacific Institute of Bioorganic Chemistry) (Official acronym in World Federation for Culture Collection – WFCC) Bacteria Marine fungi

12 This unique vessel is specially designed for hydrobiological, chemical and biochemical studies of marine macro- and microorganisms to search for organisms producing physiologically active substances with antibiotic, antitumor, immunomodulatory, and other types of effects. Built for the Pacific Institute of Bioorganic Chemistry in Finland (1985). Displacement t, Speed, designed – 15.2 knots Officers and crew - 39 persons, scientific staff – 30 persons. Officers and crew - 39 persons, scientific staff – 30 persons. Built for the Pacific Institute of Bioorganic Chemistry in Finland (1985). Displacement t, Speed, designed – 15.2 knots Officers and crew - 39 persons, scientific staff – 30 persons. Officers and crew - 39 persons, scientific staff – 30 persons.

13 There are laboratory building, diving complex, ships and boats, dwelling houses Located on the coast of picturesque Bay of Troitsa (Trinity Bay) in 100 km to the south of Vladivostok Was founded in 1967

14 Over 500 new biologically active compounds, including 2-3% of total number of presently known marine natural products were isolated and studied in Institute. The peculiarities of their biogenesis, biological effects, and taxonomical distribution were investigated Over 500 new biologically active compounds, including 2-3% of total number of presently known marine natural products were isolated and studied in Institute. The peculiarities of their biogenesis, biological effects, and taxonomical distribution were investigated

15 About 200 new biologically active compounds were isolated from different plants. Their biological effects, chemical properties, and possibilities of using as chemotaxonomic markers in higher plants systematics were studied.

16 maackolin maackiasin maackin maackin А Polyphenols of some Far-Eastern plants possessing an antioxidant activity

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18 1,3;1,6- -D-Glucans a e dc b - 3,6-О-di-substituted Glc residue - nonsubstituted Glc residue - 3-О-substituted Glc residue - 6-О-substituted Glc residue a bc from Laminaria cichorioides a bc from Fucus evanescens Soloveva T.F., Elyakova L.A., Zvyagintseva T.N., Yermak I.M. Marine Technol. Soc : 35

19 Fucoidans of brown seaweeds of the russian Far East. 2 structural types. SO 3 SO 3 SO 3 SO 3 SO 3 SO ) -α-L-Fucp-(13) -α-L-Fucp-(13) -α-L-Fucp-(13) -α-L-Fucp-(13) -α-L-Fucp-( SO 3 SO 3 SO 3 SO 3 SO 3 SO 3 3)-α-L-Fucp-(14)-α-L-Fucp-(13)-α-L-Fucp-(14)-α-L-Fucp-( SO 3 SO 3 SO 3 SO 3 1,3;1,6- -D-glucans and alginic acids are found out in some terrestrial organisms, but in the sea are distributed much more widely. Fucoidans are family of sulfated homo- and heteropolysaccharides, containing L-fucose as the basic component, and galactose, mannose, xylose, glucuronic acid in minor amounts. Fucoidans are found out only in sea organisms. 4)- [ α-L-Fucp-(13) ] n -α-L-Fucp-(14)-α-L-Fucp-(13)- [ α-L-Fucp-(14) ] m -α-L-Fucp-( SO 3 SO 3 SO 3 SO 3 SO 3 1. из Fucus evanescens 2. из Laminaria cichorioides 13 : 14 1 : 1 13 : : 1

20 Endo- and exo-1,3- -D-glucanases Alginat lyases Fucoidanases Endo-1,6- -D-glucanases Cellulases - and -D-Glucosidases - and -D-Glucosidases - and -D-Galactosidases - and -D-Galactosidases - and -D-Mannosidases - and -D-Mannosidases -L-Fucosidases -L-FucosidasesSulfatases

21 S' S''-A (reaction of transglycosylation) (reaction of transglycosylation) S A H2OH2O ESESE+SE+SES'' S''-ОН (reaction of hydrolysis) S''-S (glucanosyl transferase activity) Marine invertebrates and seaweeds are the valuable sources of the biologically active polysaccharides, the enzymes with unique specificity involved in their transformation and inhibitors of these enzymes. So, endo-1,3- -D-glucanases of marine organisms, found at first as hydrolases, catalyze three reactions running simultaneously and practically with almost equal efficiency.

22 LAMINARAN TRANSLAM immunomodulator, radioprotector, antitumor agent, cryoprotector TRANSLAM immunomodulator, radioprotector, antitumor agent, cryoprotector ANTIVIR phytoimmunostimulator: potato, tobacco, tomato, soybean ANTIVIR phytoimmunostimulator: potato, tobacco, tomato, soybean Glucose and glucooligosaccharides (Glcn, n=1,2,3 as main components) Glucose and glucooligosaccharides (Glcn, n=1,2,3 as main components) E Fractions of 1 3;1 6- -D-glucans with higher molecular masses and more branched than initial laminaran were found among the products of its enzymatic transformation by endo- 1,3- -D-glucanase. These fractions designated as Antivir" andTranslam are the products of the prominent glucanosyl transferase ability of the enzyme and its ability to catalyze synthesis not only -1 3-, but also -1 6-glucosyl links.

23 Translam and Antivir are the first biologically active polysaccharides obtained by enzymic synthesis. Preclinic trials of translam as medicine for acute radiation sickness are being finished. Translam belongs to rare medicines possessing postradiation effect. So, its injection to monkeys, irradiated with dose close to lethal one, protect about 60% of them against radiation.

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25 Above of 170 Patents and Certificates of Authorship (including several of International ones) cover processes of obtaining, syntheses and practical applications of new drugs, food suppliments, veterinary preparations, enzymes, diagnostics etc. based on the biologically active compounds from marine organisms and terrestrial higher plants. More than 20 Patents of PIBOC are used in industry. One of the first-rate factories of Far-Eastern food industry is named in the honor of our invention as «Ussuriisky Balsam». Above of 170 Patents and Certificates of Authorship (including several of International ones) cover processes of obtaining, syntheses and practical applications of new drugs, food suppliments, veterinary preparations, enzymes, diagnostics etc. based on the biologically active compounds from marine organisms and terrestrial higher plants. More than 20 Patents of PIBOC are used in industry. One of the first-rate factories of Far-Eastern food industry is named in the honor of our invention as «Ussuriisky Balsam».

26 MedicinePerfumery Leather Industry Food Industry Patent medicine was developed on the base of enzymatic preparation isolated from the crabs processing wastes.

27 Reduces the necrotic zone in fold Reduces the necrotic zone in fold Restores the functions of left ventricle Restores the functions of left ventricle Reduces the frequency of reperfusion arrhythmia Reduces the frequency of reperfusion arrhythmia Promotes the restoration of hearts contraction Promotes the restoration of hearts contraction Inhibits the erythrocytes aggregation Inhibits the erythrocytes aggregation THE RESULTS OF THE CLINICAL TESTS A highly effective preparation for prophylaxis of reperfusion damages after myocardial infarctionprophylaxis of reperfusion damages after myocardial infarction treating ischemia and infarction in acute forms.treating ischemia and infarction in acute forms.

28 Diseases of cornea (to increase epithelization); Dystrophic damages of retina and diabetic retinopathy as a retinoprotector; Proliferous processes, degeneration and hemophthalmia of various geneses; Contusions, burns and penetrating wounds of eyes; Cataract; Keratitis; Uveitis. It is prescribed for treatment of:

29 High hepato-protecting activity; High hepato-protecting activity; Hypolipidemic effect; Hypolipidemic effect; Antithrombotic effect; Antithrombotic effect; Hypocholesterinemic effect; Hypocholesterinemic effect; Antioxidative effect; Antioxidative effect; Antiatherosclerotic effect; Antiatherosclerotic effect; Non-toxic. Non-toxic. High hepato-protecting activity; High hepato-protecting activity; Hypolipidemic effect; Hypolipidemic effect; Antithrombotic effect; Antithrombotic effect; Hypocholesterinemic effect; Hypocholesterinemic effect; Antioxidative effect; Antioxidative effect; Antiatherosclerotic effect; Antiatherosclerotic effect; Non-toxic. Non-toxic. The therapeutic activity is caused by its favorable effect on the metabolism, function and structure of the liver damaged. The therapeutic activity is caused by its favorable effect on the metabolism, function and structure of the liver damaged. Inhibits free radicals and depresses the toxic products of lipid peroxidation reactions. Inhibits free radicals and depresses the toxic products of lipid peroxidation reactions. Its activity is higher than that of the well-known drugs from Silybum marianum Gaerth: Silybor, Legalon, Carsyl. Its activity is higher than that of the well-known drugs from Silybum marianum Gaerth: Silybor, Legalon, Carsyl. The therapeutic activity is caused by its favorable effect on the metabolism, function and structure of the liver damaged. The therapeutic activity is caused by its favorable effect on the metabolism, function and structure of the liver damaged. Inhibits free radicals and depresses the toxic products of lipid peroxidation reactions. Inhibits free radicals and depresses the toxic products of lipid peroxidation reactions. Its activity is higher than that of the well-known drugs from Silybum marianum Gaerth: Silybor, Legalon, Carsyl. Its activity is higher than that of the well-known drugs from Silybum marianum Gaerth: Silybor, Legalon, Carsyl.

30 As enterosorbent is well suitable for endogenous toxicoses after trauma and some diseases, such as: diseases of internal organs, acute infections of alimentary canal, suppurative processes, burns, and radiation sickness. As enterosorbent is well suitable for endogenous toxicoses after trauma and some diseases, such as: diseases of internal organs, acute infections of alimentary canal, suppurative processes, burns, and radiation sickness. Is successful as an antidote and antimutagenous remedy. Is successful as an antidote and antimutagenous remedy. Removes heavy metals from human organism. Removes heavy metals from human organism. Shows antisclerotic activity lowering cholesterol level in the blood. Shows antisclerotic activity lowering cholesterol level in the blood. Can be successful as ancillary antidiabetic remedy. Can be successful as ancillary antidiabetic remedy. Permitted in Russia as a patented medicinal and prophylactic supplement to the food stuffs. As a food supplement shows antiulcerous effect, normalizes gastrointestinal functions. As a food supplement shows antiulcerous effect, normalizes gastrointestinal functions.

31 A series of non-alcoholic balsams, which are produced from terrestrial and marine natural products, are unique remedies for rehabilitation after various diseases of gastrointestinal tract (gastritis, ulcer, disbacteriosis, colitis), cardiovascular system, hypertonia, and oncological diseases, as well as for elimination of heavy metals and radionuclides from human organism. HERBAMARIN is approved by Food Institute of the Russian Academy of Medical Sciences and recommended as a food supplement. HERBAMARIN can be manufactured with modifications in composition as tablets and capsules.

32 from Far-Eastern mussels, immunomodulator, anti-inflammatory properties, hydratant, an ingredient of make- up preparations produced by Linda, Svoboda and other factories. from Far-Eastern mussels, immunomodulator, anti-inflammatory properties, hydratant, an ingredient of make- up preparations produced by Linda, Svoboda and other factories.

33 Polymannuronic acid Fucoidan plus Immunomodulator

34 FUCOLAM-C FUCOLAM-C Substance for : Supplements Cosmetics Medicine

35 Ethanol extract of the brown alga PROPERTIES: Antioxidant Antiinflammatory action Antitumor action Immunomodilator Use for Cosmetics In ophthalmology

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