Молекула памяти P.BALABAN Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences Что-то с памятью моей стало, То, что было. - презентация

1 Молекула памяти P.BALABAN Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences Что-то с памятью моей стало, То, что было не со мной, помню…

2 + Cellular mechanisms of learning and memory have been highly conserved during evolution

3 PKmζ Protein Kinase M zeta Constitutively active isoform of Protein Kinase C (PKC) Functions in the storage of memory.

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9 Protein nitrosylation Nitrosylation is a protein modification in which a nitrosyl group is post-translationally added to a protein.proteinnitrosyl S-nitrosylation, discovered by Joseph Loscalzo, is an important biological reaction of nitric oxide; it refers to the conversion of thiol groups, including cysteine residues in proteins, to form S- nitrosothiols (RSNOs). S-Nitrosylation is a mechanism for dynamic, post-translational regulation of most or all major classes of protein.thiolcysteine

10 Known: Nitric oxide is necessary for synaptic plasticity NO in small concentrations activates protein synthesis via G-pathways, while in big concentrations LOCALLY impairs proteins functioning via S-nitrosylation mechanism. Question: ? NO is necessary both for memory formation and local memory plastification in synapses?

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14 Оксид азота необходим для модификации памяти во время реконсолидации

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