Protein nitrosylation Nitrosylation is a protein modification in which a nitrosyl group is post-translationally added to a protein.proteinnitrosyl S-nitrosylation, discovered by Joseph Loscalzo, is an important biological reaction of nitric oxide; it refers to the conversion of thiol groups, including cysteine residues in proteins, to form S- nitrosothiols (RSNOs). S-Nitrosylation is a mechanism for dynamic, post-translational regulation of most or all major classes of protein.thiolcysteine
Known: Nitric oxide is necessary for synaptic plasticity NO in small concentrations activates protein synthesis via G-pathways, while in big concentrations LOCALLY impairs proteins functioning via S-nitrosylation mechanism. Question: ? NO is necessary both for memory formation and local memory plastification in synapses?