Название представляемого доклада И. О. Автор (представляющий), Научный руководитель И. О. Ф. Название учреждения, в котором выполнена работа, Город, Страна Материалы и методыРезюме Введение Результаты Заключение Ссылки (не более 5) Краткое обоснование выбора темы и методов исследования, актуальность проблемы. Имеющиеся по данному вопросу сведения в литературе. В этих нескольких строках должна быть максимально полно отражена цель исследования, методы и материалы, основные результаты, выводы. Основные результаты исследования Можно и желательно использовать наглядный материал: рисунки, фотографии, схемы, таблицы. Материалы и методы исследования Размер позиции данного раздела на постере при необходимости может быть сокращен за счет расширения раздела «Результаты» Printed by

Differences of systemic arteries mechanical properties during remission and exacerbation of asthma T.A.Brodskaya, V.A.Nevzorova, B.I.Geltser Vladivostok State Medical University, Russia MethodsAbstract Objectives Results Conclusions References 1. Schanen J.G., Iribarren C., Shahar E. et al. Asthma and incident cardiovascular disease: the Atherosclerosis Risk in Communities Study. Thorax, 2005; 60(8): Brodskaya T.A., Geltser B.I., Nevzorova V.A., Motkina E.V. Clinical-functional estimation of arterial stiffness at the bronchial asthma. Clinical medicine. 2007; 6 : Zieman S.J., Melenovsky V., Kass D.A. Mechanisms, Pathophysiology, and Therapy of Arterial Stiffness. Arterioscler. Thromb. Vasc. Biol. 2005; 5(25): Laurent S., Cockcroft J., Van Bortel L. et al. the European Network for Non-invasive Expert consensus document on arterial stiffness: methodological issues and clinical applications Eur. Heart J. 2006; 27(21): Arteriograph TensioClinic and its program TensioClinic. Users manual. Early diagnosis of arteriosclerosis. Coexistence of cardiovascular disorders and asthma is ambiguous question. On the one hand vascular disturbances are important part of asthma pathogenesis. On the other hand the absence of serious vascular damage in asthma was remarked many times ago [1,2]. Exacerbation of asthma can associates with increase of arterial stiffness, as described recently [2]. Augmented arterial stiffness essentially influences on hemodynamics, by increasing of myocardium postloading and worsening of coronary perfusion conditions [3,4]. Increase of aortic pulse wave velocity (aPWV) can increase the risk of fatal insult and the general risk of death in such category of patients [3,4]. It is unclear whether is increase of arterial stiffness observed equally in asthma exacerbation and remission. With the purpose of research the mechanical properties of central vessels we examined 54 patients with severe and moderate asthma by noninvasive arteriography (arteriograph TensioClinic TL1 (TensioMed, Hungary)) during remission and exacerbation of disease. Control group included 25 age- and sex-matched healthy volunteers. Results: The aortal stiffness in asthma exacerbation was increased. It was expressed in increase of aortic pulse wave velocity (aPWV) and augmentation index (IA). APWV and IA in asthma remission essentially improved and have reached control level. Moreover, IA in patients with remission of severe asthma was lower, than in healthy ones (р